Prenatal treatment of congenital human cytomegalovirus infection by fetal intravascular administration of ganciclovir
β Scribed by Gracia Revello, M.; Percivalle, Elena; Baldanti, Fausto; Gerna, Giuseppe; Kustermann, Alessandra; Nava, Simona; Nicolini, Umberto
- Book ID
- 123550585
- Publisher
- Elsevier Science
- Year
- 1993
- Tongue
- English
- Weight
- 479 KB
- Volume
- 1
- Category
- Article
- ISSN
- 0928-0197
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## Abstract The reliability of the polymerase chain reaction (PCR) for prenatal diagnosis of human cytomegalovirus (HCMV) infection was determined by retrospective testing of 35 amniotic fluids identified previously as positive or negative for HCMV by virus isolation. Amniocentesis was performed in
Two major variables may cause false-negative results in prenatal diagnosis of congenital human cytomegalovirus (HCMV) infection: sensitivity of the technique(s) used; and time elapsed between maternal infection and antenatal testing. Previous results indicated that rapid HCMV isolation from amniotic