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Prenatal NAP+SAL prevents developmental delay in a mouse model of Down syndrome through effects on N-methyl-D-aspartic acid and γ-aminobutyric acid receptors

✍ Scribed by Joy Vink; Maddelena Incerti; Laura Toso; Robin Roberson; Daniel Abebe; Catherine Y. Spong

Book ID
113435062
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
368 KB
Volume
200
Category
Article
ISSN
1097-6868

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✍ Patricia Robledo; Gloria Ursu; Nicole Mahy 📂 Article 📅 1999 🏛 John Wiley and Sons 🌐 English ⚖ 766 KB

This study investigated the modulatory actions of adenosine and ␥-aminobutyric acid (GABA) on several aspects of N-methyl-Daspartate (NMDA)-induced neurotoxicity, including neuronal loss, atrophy, necrosis, and calcium accumulation in the hippocampus. For this purpose, we combined unilateral intrahi