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Prenatal diagnosis of Wolf-Hirschhorn syndrome (4p-) in association with congenital hypospadias and foot deformity

โœ Scribed by Halil Aslan; Nilay Karaca; Seher Basaran; Hayri Ermis; Yavuz Ceylan


Book ID
115009700
Publisher
BioMed Central
Year
2003
Tongue
English
Weight
374 KB
Volume
3
Category
Article
ISSN
1471-2393

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Wolf-Hirschhorn Syndrome (WHS) is caused by distal deletion of the short arm of chromosome 4 and is characterized by growth deยฎciency, mental retardation, a distinctive, `greek-helmet' facial appearance, microcephaly, ear lobe anomalies, and sacral dimples. We report a family with a balanced chromos

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## Abstract ## BACKGROUND Wolfโ€Hirschhorn syndrome (WHS) is a wellโ€known genetic condition characterized by typical facial anomalies, midline defects, skeletal anomalies, prenatal and postnatal growth retardation, hypotonia, mental retardation, and seizures. Affected patients with a microdeletion