Prenatal diagnosis of the fragile X syndrome: Possible end of the experimental phase for amniotic fluid
โ Scribed by Shapiro, Lawrence R. ;Wilmot, Patrick L. ;Murphy, Patricia D.
- Publisher
- John Wiley and Sons
- Year
- 1991
- Tongue
- English
- Weight
- 285 KB
- Volume
- 38
- Category
- Article
- ISSN
- 0148-7299
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## Abstract We have had experience with over 300 amniotic fluid specimens for prenatal diagnosis for the fragile X chromosome [fra(X)], and the flask method of tissue culture has been routinely utilized requiring extended tissue culture periods of 3โ4 weeks. The use of the in situ clonal method of
Muller et al. analysed gamma-glutamyl transpeptidase (GGTP) activity in the amniotic fluid of more than 2000 pregnant women for a prenatal diagnosis. They reported that at 18-19 weeks' gestation, two fetuses associated with lower amniotic fluid GGTP levels were diagnosed after birth as having biliar