This paper reports our experience of molecular analysis and diagnosis of B-thalassaemia and sickle cell anaemia (HbS) in 70 prospective parents of Turkish descent and their fetuses. Molecular screening was carried out by allele-specific oligonucleotide (ASO) hybridization of amplified DNA to the 12
Prenatal diagnosis of sickle cell anaemia and thalassaemia by analysis of fetal cells in maternal blood
β Scribed by Cheung, Mei-Chi; Goldberg, James D.; Kan, Yuet Wai
- Book ID
- 109918620
- Publisher
- Nature Publishing Group
- Year
- 1996
- Tongue
- English
- Weight
- 686 KB
- Volume
- 14
- Category
- Article
- ISSN
- 1061-4036
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
In this study we evaluated the performance of a system for the enrichment, identification and analysis of fetal cells in maternal peripheral blood. Blood samples were collected from women after chorionic villus sampling and enriched for the presence of nucleated erythrocytes using a three-step proc
The potential use of fetal cells circulating in maternal blood for a non-invasive prenatal diagnosis has been widely described. Several authors have developed different methods for the enrichment of fetal cells from maternal peripheral blood. The aim of this study was to make a practical valuation o