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Prenatal diagnosis of Meckel syndrome

✍ Scribed by Nico J. Leschot; Jaak J. Nef; Mies J. Becker-Bloemkolk; Marianne Verjaal; Paul F. Wiesenhaan

Publisher: Springer
Year: 1978
Tongue: English
Weight: 183 KB
Volume: 43
Category: Article
ISSN: 0340-6717
DOI: 10.1007/bf00278842

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✦ Synopsis

The three main features of Meckel syndrome are encephalocele, polycystic kidneys, and polydactyly. Prenatal diagnosis of a fetus with Meckel syndrome was made in the 16th week of gestation by means of amniotic fluid alpha1 fetoprotein estimation. The indication for amniocentesis was a previous child with an occipital meningocele and polycystic kidneys. Interpretation of the alpha1-fetoprotein value (240 microgram/ml) was difficult due to fetal blood contamination. Prenatal diagnosis is indicated in any pregnancy following the birth of a child with only two major symptoms of Meckel syndrome.

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