Prenatal diagnosis of haemoglobin Bart's disease by cordocentesis at 12–14 weeks—experience with the first 59 cases

PRENATAL DIAGNOSIS OF HAEMOGLOBIN BART'S

PRENATAL DIAGNOSIS OF HAEMOGLOBIN BART'S DISEASE BY CORDOCENTESIS AT 12–14 WEEKS' GESTATION

✍ YUNG HANG LAM; MARY HOI YIN TANG 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 195 KB 👁 2 views

Couples with alpha-thalassaemia-1 face a 25 per cent risk of having fetuses with haemoglobin (Hb) Bart's disease. Prenatal diagnosis is conventionally performed by DNA studies of chorionic villi or amniocytes obtained from chorionic villus biopsy or amniocentesis. DNA studies are expensive and time-