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Prenatal diagnosis of congenital varicella syndrome and detection of varicella-zoster virus in the fetus: a case report

✍ Scribed by John Hartung; Gisela Enders; Rabih Chaoui; Annette Arents; Cornelia Tennstedt; Rainer Bollmann

Publisher: John Wiley and Sons
Year: 1999
Tongue: English
Weight: 220 KB
Volume: 19
Category: Article
ISSN: 0197-3851
DOI: 10.1002/(sici)1097-0223(199902)19:2<163::aid-pd483>3.0.co;2-9

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✦ Synopsis

Varicella syndrome (VS) specific malformations were sonographically seen at 22 weeks and 3 days of gestation. Fetal infection was demonstrated by detection of varicella-zoster virus (VZV) DNA in fetal blood and amniotic fluid by polymerase chain reaction (PCR). Following therapeutic abortion, fetal infection was confirmed by detection of VZV DNA in several fetal tissues and placenta, and by histopathological findings like miliary calcified necroses in fetal organs.

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