Prenatal diagnosis of congenital toxoplasmosis transmitted by an immunocompetent woman infected before conception
✍ Scribed by Isabelle Villena; Cathy Chemla; Christian Quereux; Daniel Dupouy; Bernard Leroux; Frédérique Foudrinier; Jean-Michel Pinon
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 105 KB
- Volume
- 18
- Category
- Article
- ISSN
- 0197-3851
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✦ Synopsis
We report a rare case of congenital toxoplasmosis transmitted by an immunocompetent woman infected before conception. Active toxoplasmosis was suspected due to persistent lymphadenitis with specific IgM, IgA, IgE antibodies. Prenatal diagnosis based on amniocentesis and fetal blood sampling at 24 weeks' amenorrhoea was positive on amniotic fluid, and fetal infection was confirmed after termination.
In our opinion such cases need the same monitoring as when seroconversion occurs during the first trimester. A pregnancy-free interval of six to nine months is recommended after proven patent toxoplasmosis seroconversion.