Prenatal diagnosis of a heterozygous carrier of premature chromatid separation (PCS) trait

Induction of premature chromatid separat

Induction of premature chromatid separation (PCS) in individuals with PCS trait and in normal controls

✍ Ikeuchi, Tatsuro ;Yang, Zeng-Quan ;Wakamatsu, Kyoko ;Kajii, Tadashi 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 124 KB

## Abstract Cultured peripheral blood lymphocytes from ten normal individuals, treated with 0.075 M KCl at 37°C for 20 min, showed 0–2% cells in premature chromatid separation (PCS), a configuration with split centromeres and chromatids of most or all chromosomes. When treated for 30 min, they incr