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Prenatal diagnosis of a familial interchromosomal insertion of Y chromosome heterochromatin

โœ Scribed by Ashton-Prolla, Patricia; Gershin, Irina F.; Babu, Arvind; Neu, Richard L.; Zinberg, Randi E.; Willner, Judith P.; Desnick, Robert J.; Cotter, Philip D.

Publisher
John Wiley and Sons
Year
1997
Tongue
English
Weight
10 KB
Volume
73
Category
Article
ISSN
0148-7299
DOI
10.1002/(sici)1096-8628(19971231)73:4<470::aid-ajmg17>3.0.co;2-o

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โœฆ Synopsis

An apparently unbalanced karyotype containing an abnormal chromosome 11 was identified in a 16-week female fetus by analysis of cultured amniocytes. Fluorescence in situ hybridization (FISH) with a chromosome 11 paint identified the presence of an insertion in band 11q24. Parental karyotyping documented an unbalanced karyotype with the same der(11) chromosome in the phenotypically normal father. CBG-banding and FISH identified the insertion to be Yq12 heterochromatin: 46,XY, der(11)ins(11;Y)(q24;q12q12).ish der(11) (wcp11+,DYZ1+). The same der(11) chromosome was also found in the phenotypically normal paternal grandmother, demonstrating this additional Y chromosomal material did not affect normal female sexual development or fertility. The parents elected to continue the pregnancy and a normal girl was born at term, further confirming that this rare familial variant has no clinical significance. This case illustrates the importance of family studies, appropriate banding, and FISH analyses to accurately characterize apparent chromosomal abnormalities. Am.

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