✦ LIBER ✦

Prenatal confirmation of true fetal trisomy 22 mosaicism by fetal skin biopsy following normal fetal blood sampling

✍ Scribed by Vincenzo Berghella; Ronald J. Wapner; T. Yang-Feng; Maurice J. Mahoney

Publisher: John Wiley and Sons
Year: 1998
Tongue: English
Weight: 66 KB
Volume: 18
Category: Article
ISSN: 0197-3851
DOI: 10.1002/(sici)1097-0223(199804)18:4<384::aid-pd263>3.0.co;2-4

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✦ Synopsis

Trisomy 22 mosaicism diagnosed at 20 weeks' gestation by amniocentesis in a 35-year-old woman was not confirmed by fetal blood sampling. Subsequent fetal skin biopsy revealed trisomy 22 in 7 of the 15 fibroblasts analysed. We conclude that, depending on the chromosome involved, fetal skin biopsy should be considered in the diagnostic work-up when mosaicism is found in amniotic fluid.