Development of the large intestine in the insectivore Suncus murinus (the laboratory shrew) was investigated from day 21 to 30 of gestation and from birth to 20 days of age. Two days before birth, the stratified epithelium in the large intestine changed into a single layer. Although neither villi nor villus-like structures were ever present, fissures, corresponding to openings of the crypts, appeared on the mucosal surface before birth. These increased in number as well as in width and depth, connected with each other, and gave the mucosal surface a ridge-like appearance by 20 days of age. An elevation containing submucosae appeared shortly after birth and formed a large circular fold during the neonatal period. Goblet cells were the predominant epithelial cell type. Individual epithelial cells were mature-looking a few days before birth; goblet cells contained numerous mucous globules and absorptive cells possessed well-developed organelles. However, although goblet cells increased in number and exhibited active mucousreleasing forms after birth, absorptive cells never showed morphologic evidence of active endocytosis, such as apical endocytotic complexes and large supranuclear vacuoles. Each eDithelia1 cell was similar in ultrastructure to that of the adult shortly after birth.