Premixed acidic calcium phosphate cement: Characterization of strength and microstructure

✍ Scribed by J. Aberg; H. Brisby; H. B. Henriksson; A. Lindahl; P. Thomsen; H. Engqvist

• Publisher: John Wiley and Sons
• Year: 2010
• Tongue: English
• Weight: 414 KB
• Volume: 93B
• Category: Article
• ISSN: 1552-4973
• DOI: 10.1002/jbm.b.31600

✦ Synopsis

Abstract

By using a premixed calcium phosphate cement (CPC), the handling properties of the cement are drastically improved, which is a challenge for traditional injectable CPCs. Previously premixed cements have been based on apatitic cements. In this article, acidic cement has been developed and evaluated. Monocalcium phosphate monohydrate and β‐tricalcium phosphate were mixed with glycerol to form a paste. As the paste does not contain water, no setting reaction starts and thus the working time is indefinite. Powder/liquid ratios (P/L) of 2.25, 3.5 and 4.75 were evaluated. Setting time (ST) and compressive strength (CS) were measured after 1 day, 1 week and 4 weeks in phosphate buffered saline (PBS) solution, and the corresponding microstructure was evaluated using electron microscopy and X‐ray diffraction. The ST started when the cements were placed in PBS and ranged from 28 to 75 min, higher P/L gave a lower ST. Higher P/L also gave a higher CS, which ranged from 2 to 16 MPa. The microstructure mainly consisted of monetite, 1–5 μm in grain size. After 4 weeks in PBS, the strength increased. As acidic cements are resorbed faster in vivo, this cement should allow faster bone regeneration than apatitic cements. Premixed cements show a great handling benefit when compared with normal CPCs and can be formulated with similar ST and mechanical properties. © 2010 Wiley Periodicals, Inc. J Biomed Mater Res Part B: Appl Biomater 2010