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Premature ovarian failure with FMR1 premutation, X chromosome mosaicism and blood lymphocyte microchimerism

โœ Scribed by Gersak, K.; Franic, D.; Veble, A.; Pajnic, I. Zupanic; Teran, N.; Writzl, K.


Book ID
125509074
Publisher
Informa plc
Year
2010
Tongue
English
Weight
321 KB
Volume
14
Category
Article
ISSN
1369-7137

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X chromosome inactivation does not defin
โœ Marian A. Spath; Willy N. Nillesen; Arie P.T. Smits; Ton B. Feuth; Didi D.M. Bra ๐Ÿ“‚ Article ๐Ÿ“… 2010 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 159 KB ๐Ÿ‘ 2 views

## Abstract Since only 20% of female fragile X premutation carriers develop premature ovarian failure (POF, i.e., amenorrhea before age of 40 years), and since X chromosome inactivation (XCI) determines the phenotypic severity of full mutation women, we reasoned that the development of POF in fragi