Preliminary study of potential antiarrhythmic effects of Crataegus monogyna

✍ Scribed by Emmanuel B. Thompson; George H. Aynilian; Paul Gora; Norman R. Farnsworth

• Publisher: John Wiley and Sons
• Year: 1974
• Tongue: English
• Weight: 236 KB
• Volume: 63
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600631222

✦ Synopsis

Crude extracts of the bark and leaves of Crataegus rnonogyna were tested in rabbits for potential antiarrhythmic activity. Four fractions (A contained the petroleum ether solubles, B contained the 95% ethanol solubles, C contained the chloroform solubles, and D contained the water solubles), which were infused 5 min after arrhythmia had been induced by intravenous injection of 10 rg/kg of aconitine, did not cause the arrhythmia to revert t o normal cardiac rhythm. However, when the maximal tolerated amounts of either Fraction B or D of the bark or leaves were first infused, higher doses of aconitine than those used in control animals were required to generate arrhythmias in the treated rabbits. The present study showed that the extracts from bark and leaves of C. monogyna possess a prophylactic antiarrhythmic activity. Keyphrases 0 Crataegus rnonogyna L. (Rosaceae)-antiarrhythmic effects of crude extracts of bark and leaves Medicinal plants-C. monogyna, crude extracts of leaves and bark screened for antiarrhythmic effects 0 Antiarrhythmic activity-C. monogyno leaf and bark extracts screened