Comb in a tio n Ch em o therapy with Cis-Dia m m in e dic h lo ropla tin um , On c o vin , an d Bleo m ycin (COB) in Advanced Head and Neck Cancer Phase I1 MAGID H. AMER, MD, FRCS (ENG.), FRCP(C),\* RONALD M. IZBICKI, DO,\* V. K. VAITKEVICIUS, MD, FACP,t AND MUHYI AL-SARRAF, MD, FRCP(C), FACP\* Twen
Preliminary study of a combination of adriamycin, bleomycin, and diamminedichloroplatinum in advanced cancer
โ Scribed by Decker, David A. ;Edmonson, John H. ;Eagan, Robert T.
- Publisher
- John Wiley and Sons
- Year
- 1978
- Tongue
- English
- Weight
- 215 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0098-1532
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Twenty-seven patients with assessable, regionally advanced, or metastatic upper aerodigestive cancer of diverse histology received a combination of mitomycin C, adriamycin, and cisdiamminedichloroplatinum. All patients had previously received extensive surgery and/or radiation therapy. We observed a
Fourteen patients with advanced head and neck carcinomas received a monthly intravenous regimen of Adriamycin, 40 mg/m2, day 1; cyclophosphamide, 400 mg/m2, day 3; and cis-diamminedichloroplatinum, 20 mg/m2/1 hour, days 1-3 (CAP-3). A regression rate of only 7% (0112 squamous cell carcinomas; 112 ad