Preliminary results of interstitial motexafin lutetium-mediated PDT for prostate cancer

✍ Scribed by K.L. Du; R. Mick; T.M. Busch; T.C. Zhu; J.C. Finlay; G. Yu; A.G. Yodh; S.B. Malkowicz; D. Smith; R. Whittington; D. Stripp; S.M. Hahn

• Publisher: John Wiley and Sons
• Year: 2006
• Tongue: English
• Weight: 126 KB
• Volume: 38
• Category: Article
• ISSN: 0196-8092
• DOI: 10.1002/lsm.20341

✦ Synopsis

Abstract

Background and Objectives

Interstitial photodynamic therapy (PDT) is an emerging modality for the treatment of solid organ disease. Our group at the University of Pennsylvania has performed extensive studies that demonstrate the feasibility of interstitial PDT for prostate cancer. Our preclinical and clinical experience is herein detailed.

Study Design/Materials and Methods

We have treated 16 canines in preclinical studies, and 16 human subjects in a Phase I study, using motexafin lutetium‐mediated PDT for recurrent prostate adenocarcinoma. Dosimetry of light fluence, drug level and oxygen distribution for these patients were performed.

Results

We demonstrate the safe and comprehensive treatment of the prostate using PDT. However, there is significant variability in the dose distribution and the subsequent tissue necrosis throughout the prostate.

Conclusions

PDT is an attractive option for the treatment of prostate adenocarcinoma. However, the observed variation in PDT dose distribution translates into uncertain therapeutic reproducibility. Our future focus will be on the development of an integrated system that is able to both detect and compensate for dose variations in real‐time, in order to deliver a consistent overall PDT dose distribution. Lasers Surg. Med. 38:427–434, 2006. © 2006 Wiley‐Liss, Inc.