Preliminary report on the effect of the nitric oxide donor SIN-1 on human cavernous tissue in vivo

✍ Scribed by C. G. Stief; F. Holmquist; E. P. Allhoff; K. E. Andersson; U. Jonas

• Publisher: Springer-Verlag
• Year: 1991
• Tongue: English
• Weight: 277 KB
• Volume: 9
• Category: Article
• ISSN: 0724-4983
• DOI: 10.1007/bf00182848

✦ Synopsis

Recent experimental studies showed an important role o f endothelium-derived relaxing factor in penile erection. Therefore, an in vivo study was done to examine the effect o f the nitric oxide d o n o r SIN-I on h u m a n erection. Eight patients with erectile dysfunction received doses o f 0.1 to 1 mg SIN-1 intracavernously. In all patients, SIN-1 induced a dose-dependent erectile response. A l t h o u g h applied in 2 patients with prolonged erections to minimal doses o f a p a p a v e r i n e -p h e n t o l a m i n e combination, the d u r a t i o n of the full erection achieved in response to 1 mg SIN-1 was limited to about 60 min. The erectile response was due to an increase in arterial inflow and to cavernous s m o o t h muscle relaxation. There were no systemic or local side-effects. Our preliminary study suggests SIN-1 to be an attractive alternative for autoinjection therapy in the treatment o f erectile dysfunction.