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Preliminary experience with chemotherapy in advanced salivary gland neoplasms

✍ Scribed by Belani, Chandra P. ;Eisenberger, Mario A. ;Gray, William C.


Publisher
John Wiley and Sons
Year
1988
Tongue
English
Weight
390 KB
Volume
16
Category
Article
ISSN
0098-1532

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✦ Synopsis


Eight patients with advanced incurable salivary gland carcinoma were treated with the combination of cyclophosphamide, doxorubicin, and cisplatin (CAP). There were three clinical complete responses and two excellent partial responses. One of the three nonresponders had symptomatic improvement without any response in the measurable dis-ease sites. Side effects were acceptable. All patients had moderate nausea and some degree of vomiting, which were adequately controlled by antiemetics. These results are preliminary but when considered with other reported trials using the same combination suggest an active treatment program for advanced neoplasms of the salivary glands.


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Chemotherapy of advanced salivary gland
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## Abstract ## Background Epithelial neoplasms of salivary gland origin are relatively uncommon in children and adolescents. Over a 44‐year period, there were 38 cases affecting children under 19 years of age in our Pediatric Hospital‐Based Tumor Registry. ## Procedure Medical charts of 38 patie