Pregnenolone sulfate increases the convulsant potency of N-methyl-D-aspartate in mice
β Scribed by Sabatino Maione; Liberato Berrino; Saverio Vitagliano; Juan Leyva; Francesco Rossi
- Book ID
- 115887810
- Publisher
- Elsevier Science
- Year
- 1992
- Tongue
- English
- Weight
- 239 KB
- Volume
- 219
- Category
- Article
- ISSN
- 0014-2999
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
## Abstract Among the different steroids found in the brain, pregnenolone sulfate (3Ξ²βhydroxyβ5βpregnenβ20βoneβ3βsulfate; PREGS) is known to enhance hippocampalβassociated memory. The present study employs rat hippocampal slices to investigate the ability of PREGS to modulate longβterm potentiation
Studies in which glutamate (GLU) neurotransmission has been reduced at striatal synapses have shown that GLU influences the biosynthesis of certain peptide cotransmitters by striatal neurons. The present experiment was designed to test the effects of direct activation of the NMDA or AMPA types of GL