Pregnane-x-receptor controls hepatic glucuronidation during pregnancy and neonatal development in humanized UGT1 mice

The liver X-receptor alpha controls hepa

The liver X-receptor alpha controls hepatic expression of the human bile acid–glucuronidating UGT1A3 enzyme in human cells and transgenic mice

✍ Mélanie Verreault; Kathy Senekeo-Effenberger; Jocelyn Trottier; Jessica A. Bonzo 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 741 KB

Glucuronidation, an important bile acid detoxification pathway, is catalyzed by enzymes belonging to the UDP-glucuronosyltransferase (UGT) family. Among UGT enzymes, UGT1A3 is considered the major human enzyme for the hepatic C24-glucuronidation of the primary chenodeoxycholic (CDCA) and secondary l