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Pregnane X receptor- and CYP3A4-humanized mouse models and their applications

โœ Scribed by Jie Cheng; Xiaochao Ma; Frank J Gonzalez

Book ID
111219762
Publisher
Nature Publishing Group
Year
2011
Tongue
English
Weight
821 KB
Volume
163
Category
Article
ISSN
0007-1188

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CYP3A4 and pregnane X receptor humanized
CYP3A4 and pregnane X receptor humanized mice
โœ Frank J. Gonzalez ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 206 KB

## Abstract Marked species differences exist in P450 expression and activities. In order to produce mouse models that can be used to more accurately predict human drug and carcinogen metabolism, P450โ€ and xenobiotic receptor humanized mice are being prepared using bacterial artificial chromosomes (