Pregnancy in a hermaphrodite with a male-predominant mosaic karyotype
โ Scribed by Samantha A. Schoenhaus; Scott E. Lentz; Peter Saber; Malcom G. Munro; Seth Kivnick
- Book ID
- 116472820
- Publisher
- Elsevier Science
- Year
- 2008
- Tongue
- English
- Weight
- 234 KB
- Volume
- 90
- Category
- Article
- ISSN
- 1556-5653
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## Abstract Abnormal recombination between the X and Y chromosomes during meiosis, occurring outside the pseudoautosomal region, can result in translocation of the __SRY__ gene from the Y to the X chromosome, and consequently in abnormal sexual differentiation, such as the development of 46,XX male
The first case (to the authors' knowledge) is reported of a true hermaphrodite with bilateral ovotestes, bilateral gonadoblastomas and dysgerminomas, a 46, XX/46,XY karyotype, and a successful pregnancy. The true hermaphroditism was diagnosed during infancy. The patient was subsequently found to hav