Pregnancy during hodgkin's disease

✍ Scribed by Chester M. Southam; Henry D. Diamond; Lloyd F. Craver

• Publisher: John Wiley and Sons
• Year: 1956
• Tongue: English
• Weight: 563 KB
• Volume: 9
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/1097-0142(195611/12)9:6<1141::aid-cncr2820090612>3.0.co;2-e

✦ Synopsis

I cation of pregnancy by Hodgkin's disease kin's disease were excluded from this study. is a rare event. On the other hand, in the For each pregnancy a card was prepared on practice of the physician who sees large num-which the following data were recorded: basic bers of lymphoma cases, this complication is identifying data; outcome of pregnancy; by no means rare, since the onset of Hodgkin's health of child to last available record; breast disease usually occurs within the child-bearing feeding; date of conception; date of onset of period and appears to have little effect on Hodgkin's disease by history; date of tissue dipregnancy rate. It is thus of interest and im-agnosis of Hodgkin's disease; time in months portance to know the possible effects of from onset of Hodgkin's disease (by history Hodgkin's disease on the course of pregnancy and by tissue diagnosis) to death, and from and on the child and, conversely, the effect of conception to onset of Hodgkin's disease; and pregnancy and labor on the course of Hodg-extent, location, symptomatology, progression, kin's disease. There have been many previous and treatment of the Hodgkin's disease during publications on this subject, each of which pregnancy, during the nine months preceding reports from one to twelve new cases of preg-conception, and during the nine months after nancy complicating Hodgkin's disease for a delivery. total of approximately one hundred fifty cases

The extent of disease was designated acreported to date. T h e conclusion reached in cording to Craver's classification. Class I is several of these reports1* o,', 8212 is that Hodg-unicentric disease without constitutional sympkin's disease does not affect pregnancy and toms or other evidences of dissemination. pregnancy does not influence the course of Class-I1 disease is characterized by involve-Hodgkin's disease. T h e present study was un-ment of two adjacent areas, suggesting spread dertaken because the experience in Memo-from the point of origin along lymphatic rial Center for Cancer and Allied Dis-channels to regional lymph nodes. There may eases does not permit unqualified acceptance or may not be constitutional symptoms. The of those conclusions and because it is apparent commonest example of class-I1 Hodgkin's disthat the small number of cases presented in case is that with masses limited to mediasprevious series did not permit consideration tinum and neck (unilateral or bilateral). of the tremendous variability in the natural Class-111 disease is generalized and often accourse of this diseasc. A complete review of companied by constitutional signs and sympthe literature is not attempted in this paper toms, such as pruritus, night sweats, fever, but is planned for a future publication. and anemia. This classification is used to indicate maximum detectible extent of disease. Since complete eradication of the disease can never be presumed, it follows that the class designation cannot diminish. However, all evidence of disease activity may disappear and, if an area of disease shows no activity for a long time, the disease is considered dormant (rather than cured), In this study a patient is designated as having dormant disease (of class I, 11, or From the Medical Neoplasia Service, Department of 111) if no anti-Hodgkin's-disease treatment Medicine, Memorial Center for Cancer and Allied Dis-was given and there was no evidence of diseases,