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Pregnancy-associated glycoprotein (α2-pag) - A possible marker in breast cancer?

✍ Scribed by Nils Wilking; Kjell Carlström; Sven A. Gustafsson; Leif Karnström; Bo Von Schoultz

Book ID
102277971
Publisher
John Wiley and Sons
Year
1984
Tongue
French
Weight
302 KB
Volume
34
Category
Article
ISSN
0020-7136

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✦ Synopsis

Serum levels of pregnancy-associated a-glycoprotein (a,-PAG) and estradiol-178 (Ed and the estrogen receptor content (ER) in the tumor cytosol were measured in 174 women aged 24 to 94 years with primary breast cancer and the values were related to patient age, tumor size and clinical stage. While El levels were significantly lower and ER values significantly higher in older women, no significant correlation was found between a,-PAG on one hand and the'patients' age, El or ER values or tumor size on the other. A significant positive correlation (p= 0.0 16, Pearson correlation test) was found between a,-PAC values and the clinical stage of the tumor. The results suggest the possible use of a,-PAG as a marker for the monitoring of disseminated breast cancer during systemic therapy.

📜 SIMILAR VOLUMES

Pregnancy-associated alpha2 glycoprotein
Pregnancy-associated alpha2 glycoprotein (α2PAG) synthesis by human breast cancer tissue and cultured cell lines
✍ Edward J. Sarcione; Daniel Delluomo; Martin Zloty 📂 Article 📅 1983 🏛 John Wiley and Sons 🌐 French ⚖ 517 KB

Elevated a,PAG serum levels are found in pregnant women and patients with diverse types of neoplasms including breast cancer. Primary human breast cancer tissue, MCF-7 and BT-20 human breast cancer cultured cell lines were shown to synthesize a,PAG in vitro. BT-20 breast cancer cells also released t