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Pregabalin and gabapentin inhibit substance P-induced NF-κB activation in neuroblastoma and glioma cells

✍ Scribed by Seyeon Park; Eun Sook Ahn; Dong Woo Han; Jong Hwa Lee; Kyung Tae Min; Hyunkyung Kim; Yong-Woo Hong

Publisher
John Wiley and Sons
Year
2008
Tongue
English
Weight
334 KB
Volume
105
Category
Article
ISSN
0730-2312

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✦ Synopsis

Abstract

Pregabalin and gabapentin are lipophilic amino acid derivatives of γ‐amino butyric acid that show anticonvulsant and analgesic activity against neuropathic pain. In this study, we investigated their actions on substance P‐induced NF‐κB activation in human neuroblastoma and rat glioma cells. Pregabalin and gabapentin decreased substance P‐induced NF‐κB activation in these cells. These drugs also inhibited NF‐κB activation in rat spinal dorsal root ganglia cells pre‐treated in vitro with substance P. These results suggest a previously undefined role of pregabalin and gabapentin in the regulation of inflammation‐related intracellular signaling in both neuronal and glial cells. J. Cell. Biochem. 105: 414–423, 2008. © 2008 Wiley‐Liss, Inc.

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