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Prefrontal cortical dysfunction and genetic polymorphisms of the COMT gene in subjects with schizophrenia: A genetic study of a schizophrenia endophenotype

โœ Scribed by I. Wonodi; C. Stine; B. Mitchell; J. Gold; R. Buchanan; G.K. Thaker


Book ID
119555743
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
183 KB
Volume
60
Category
Article
ISSN
0920-9964

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Several linkage studies suggested chromosome 22q11-13 may harbor susceptible genes for schizophrenia. Catechol-0methyl-transferase t:COMT), which is involved in the metabolism of catecholamines, was mapped to 22q'll and is considered a possible candidate gene for schizophrenia. Recently, we identifi