Preformulation study of nicergoline solid dispersions
β Scribed by Censi, Roberta; Martena, Valentina; Hoti, Ela; Malaj, Ledjan; Martino, Piera
- Book ID
- 121542645
- Publisher
- Springer Netherlands
- Year
- 2013
- Tongue
- English
- Weight
- 563 KB
- Volume
- 115
- Category
- Article
- ISSN
- 0022-5215
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Pelrinone HCl is essentially nonhygroscopic. The pH-solubility profile exhibits a U-shaped curve, while the octanol-water partition coefficient-pH profile shows a bell-shaped curve. Two ionizable functions, with a pKa1 value of 4.71 and a pKa2 value of 8.94, produce the cationic and anionic forms, r