Preformulation study of pelrinone hydroc
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Joseph Hajdu; Gloria Adams; Hyuk-Koo Lee
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Article
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1988
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John Wiley and Sons
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English
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Pelrinone HCl is essentially nonhygroscopic. The pH-solubility profile exhibits a U-shaped curve, while the octanol-water partition coefficient-pH profile shows a bell-shaped curve. Two ionizable functions, with a pKa1 value of 4.71 and a pKa2 value of 8.94, produce the cationic and anionic forms, r