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Preferred hydrolysis of methyl d-pyroglutamates (5-carbomethoxy-2-pyrrolidones) by α-chymotrypsin

✍ Scribed by Thomas Gillan; Gideon Mor; Frederick W. Pepper; Saul G. Cohen


Publisher
Elsevier Science
Year
1977
Tongue
English
Weight
801 KB
Volume
6
Category
Article
ISSN
0045-2068

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The Ferrier rearrangement of a methyl a-D-mannopyranoside derivative (Sa), followed by a stereoselective reduction gave a L-ch/ro-inositol derivative (2), which was converted to L-chiro-inositol 1,2,3-trisphosphate (3) and L-chiro-inositol 1,2,3,5-tetrakisphosphate (4). Compounds 3 and 4 may be cons