Preferential Solvation of Organic Species in Binary Solvent Mixtures Probed by Intermolecular 1H NOESY NMR Spectroscopy
✍ Scribed by Alessandro Bagno; Marco Campulla; Matteo Pirana; Gianfranco Scorrano; Stefano Stiz
- Publisher
- John Wiley and Sons
- Year
- 1999
- Tongue
- English
- Weight
- 174 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0947-6539
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✦ Synopsis
The preferential solvation of neutral and ionic organic species (phenol, nitroanilines, N-methylbutyramide, 1,4-dioxane, acetate and tetraalkylammonium ions) in binary solvent mixtures (aqueous CH 3 CN, DMSO, EtOH, 1-PrOH, CH 3 CON(CH 3 ) 2 ; CH 2 Cl 2 /Et 2 O; 1,4-dioxane/benzene; cyclohexane/THF) has been investigated through the analysis of the relative intensities of intermolecular 1 H NOESY cross-peaks according to Macura ± Ernst theory. Observed preferential solvation is discussed in terms of the strength of individual solute ± solvent interactions, hydrophobic interactions in water-rich mixtures, and microheterogeneity in the mixed medium.