Preferential retroviral-mediated transduction of EBV- and CMV-specific T cells after polyclonal T-cell activation
✍ Scribed by Sauce, D; Mercier, P; Battini, J-L; Ferrand, C; Certoux, J-M; Manel, N; Taylor, N; Duperrier, A; Hervé, P; Tiberghien, P
- Book ID
- 110039564
- Publisher
- Nature Publishing Group
- Year
- 2004
- Tongue
- English
- Weight
- 123 KB
- Volume
- 11
- Category
- Article
- ISSN
- 0969-7128
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📜 SIMILAR VOLUMES
Efficient protocols to generate cytomegalovirus (CMV)-specific T cells are required for adoptive immunotherapy. Recombinant Epstein-Barr virus (EBV) vectors called mini-EBV can be used to establish permanent B cell lines in a single step, which present the CMV antigen pp65 in a constitutive manner.
Controversial data have been reported regarding the ability of peripheral blood T cells to secrete interferon-y (IFN-y) and interleukin-4 (IL-4) from atopic patients as compared to nonatopic healthy controls. In most of these studies, T cells in peripheral blood mononuclear cell preparations (PBMC)