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Preferential mutation of paternally derived RB gene as the initial event in sporadic osteosarcoma

✍ Scribed by Toguchida, Junya; Ishizaki, Kanji; Sasaki, Masao S.; Nakamura, Yusuke; Ikenaga, Mituo; Kato, Mitsuo; Sugimot, Masayuki; Kotoura, Yoshihiko; Yamamuro, Takao

Book ID: 109758183
Publisher: Nature Publishing Group
Year: 1989
Tongue: English
Weight: 313 KB
Volume: 338
Category: Article
ISSN: 0028-0836
DOI: 10.1038/338156a0

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Preferential mutation of the neurofibrom

Preferential mutation of the neurofibromatosis type 1 gene in paternally derived chromosomes

✍ Karen Stephens; Lucille Kayes; Vincent M. Riccardi; Marcia Rising; Virginia P. S 📂 Article 📅 1992 🏛 Springer 🌐 English ⚖ 445 KB

An interesting feature of neurofibromatosis type 1 (NF1) is its high mutation rate of 1 x 10 -4 per gamete per generation. The molecular basis for frequent NFI mutation in unknown; the gene is not deletion prone. We have found that in all ten families examined, the apparent new NF1 mutation occurred