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Preferential incorporation of [3H]thymidine into polypyrimidine-containing regions in DNA following ultraviolet irradiation of human cells

✍ Scribed by H.C. Birnboim; M.C. Paterson


Book ID
118918038
Publisher
Elsevier Science
Year
1978
Tongue
English
Weight
455 KB
Volume
121
Category
Article
ISSN
0022-2836

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Preferential incorporation of 3β€²-azido-2
✍ Ofelia A. Olivero; Miriam C. Poirier πŸ“‚ Article πŸ“… 1993 πŸ› John Wiley and Sons 🌐 English βš– 745 KB

## Abstract 3′‐Azido‐2β€²,3′‐dideoxythymidine (azidothymidine; AZT) induces bone marrow toxicity in patients chronically given therapeutic doses of drug and is tumorigenic in rodents, inducing squamous cell tumors in vaginal tissues of mice and rats. In the study reported here, we explored the incorp