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Preferential effects of the chemotherapeutic DNA crosslinking agent mitomycin C on inducible gene expression in vivo

✍ Scribed by Rosemary M. Caron; Dr. Joshua W. Hamilton

Publisher: John Wiley and Sons
Year: 1995
Tongue: English
Weight: 849 KB
Volume: 25
Category: Article
ISSN: 0893-6692
DOI: 10.1002/em.2850250103

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## Previous studies in our laboratory have demonstrated that genotoxic chemical carcinogens have strong preferential effects on expression of certain inducible genes at nonovertly toxic doses in vivo. The effects of the DNA cross-linking agent and chemotherapy drug, mitomycin C (MMC), on expressio