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Preferential chromosome loss in human papilloma virus DNA-lmmortalized mammary epithelial cells

✍ Scribed by Karen Swisshelm; Michele Leonard; Dr. Ruth Sager

Publisher: John Wiley and Sons
Year: 1992
Tongue: English
Weight: 751 KB
Volume: 5
Category: Article
ISSN: 1045-2257
DOI: 10.1002/gcc.2870050308

No coin nor oath required. For personal study only.

✦ Synopsis

Human papilloma virus (HPV) DNA-immortalized human mammary epithelial cells may provide a model system for studying the molecular basis of immortalization and its role in breast neoplasia. Cytogenetic analyses were performed on clones derived from HPV 16and HPV 18-immortalized human mammary epithelial cells. The majority of the clones contained near-diploid karyotypes. The single most frequent whole-chromosome loss was that of chromosome 19. Regions that showed preference for deletion and/or translocation included Zpter, I I qter, and I5pter. Evidence of chromosome I 9 loss was confirmed by polymerase chain reaction (PCR)-generated, chromosome I9-specific, dinucleotide microsatellite repeat polymorphism analysis. Genes Chrorn Concer 5 2 19-226 ( I 992). 0 I992 Wiley-Liss, Inc.

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