Tyrosine hydroxylase (TH) is a candidate gene extensively explored in several association studies of bipolar disorder (BD). However, because of conflicting results of independent studies and low statistical power of individual studies to detect small differences between cases and controls, reliable
Preferential association between childhood emotional abuse and bipolar disorder
✍ Scribed by Bruno Etain; Flavie Mathieu; Chantal Henry; Aurélie Raust; Isabelle Roy; Anne Germain; Marion Leboyer; Frank Bellivier
- Publisher
- Springer
- Year
- 2010
- Tongue
- English
- Weight
- 120 KB
- Volume
- 23
- Category
- Article
- ISSN
- 0894-9867
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Childhood trauma has been suggested to be involved in the susceptibility to bipolar disorder. However, case‐control studies are lacking, and the preferential implication and the dose‐effect of different trauma subtypes remain poorly investigated. Two hundred six bipolar patients and 94 controls completed the Childhood Trauma Questionnaire (CTQ; Bernstein et al., 1994). The CTQ total score was higher for bipolar patients than for controls. The presence of multiple trauma was significantly more frequent in bipolar patients than in controls (63% vs. 33%). Multiple logistic regression suggested that only emotional abuse was associated with bipolar disorder with a suggestive dose‐effect. Clinical practice should include systematic assessment of childhood trauma among bipolar patients with a particular focus on emotional abuse.
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