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Preferential and absolute interactions of solvent components with proteins in mixed solvent systems

✍ Scribed by Hideo Inoue; Serge N. Timasheff

Publisher
Wiley (John Wiley & Sons)
Year
1972
Tongue
English
Weight
427 KB
Volume
11
Category
Article
ISSN
0006-3525

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✦ Synopsis

An equation is derived relating total and preferential interactions of solvent components with macromolecules in a three-component system. Application of this equation to literature data shows that binding of non-polar solvents to proteins parallels the unfolding of the latter. This observation is discussed in terms of local inter-residue and residue-solvent interactions.

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