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Preferential adsorption of high density lipoprotein (HDL) in blood plasma/polymer interaction

✍ Scribed by Bantjes, A. ;Breemhaar, W. ;Beugeling, T. ;Brinkman, E. ;Ellens, D. J.

Publisher: Wiley (John Wiley & Sons)
Year: 1985
Weight: 165 KB
Volume: 9
Category: Article
ISSN: 0025-116X
DOI: 10.1002/macp.1985.020091985112

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✦ Synopsis

A few studies on the adsorption of plasma proteins to polymeric surfaces show that major plasma proteins: albumin (Alb), fibrinogen (Fb) and immunoglobulin (IgG) are adsorbed in much smaller quantities from plasma than from protein solutions ( 1 , Z ) . Present results show that this difference in adsorption is due to the preferential adsorption of high density lipoprotein from plasma onto the material surfaces studied (PVC and PS).

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## Abstract Apolipoprotein AI (apo AI) is the major protein component of high density lipoprotein (HDL), and represents ∼1% of the total protein content of plasma. In previous work, apo AI was identified as a major component of the protein layers adsorbed from plasma to biomaterials having a wide r