✦ LIBER ✦

Preference for Axial N -Alkylation of Tetrahydro-1,3-oxazines and Hexahydropyrimidines: Manifestation of a Kinetic Anomeric Effect

✍ Scribed by Berges, David A.; Fan, Jianmei; Devinck, Sylvie; Mower, Kendall

Book ID: 118042394
Publisher: American Chemical Society
Year: 2000
Tongue: English
Weight: 108 KB
Volume: 65
Category: Article
ISSN: 0022-3263
DOI: 10.1021/jo991752i

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Quantitive dependence of N-methyl invers

Quantitive dependence of N-methyl inversion barriers in six-membered rings on electronic and steric effects. Direct observation of the conformational equilibria in tetrahydro-1,3-oxazines and hexahydropyrimidines

✍ Ferguson, Ian J.; Katritzky, Alan R.; Read, David M. 📂 Article 📅 1975 🏛 The Royal Society of Chemistry 🌐 English ⚖ 194 KB

Synthesis of the Nonpeptide Renin Inhibi

Synthesis of the Nonpeptide Renin Inhibitor A-68064 and the ACE Inhibitor Methyl Enalaprilat from (5S)-2,3,5,6-Tetrahydro-5-alkyl-N-(tert-butyloxycarbonyl-4H-1,4-oxazine-2-ones

✍ William R. Baker; Stephen L. Condon 📂 Article 📅 1992 🏛 Elsevier Science 🌐 French ⚖ 218 KB

## The nonpeptide renin inhibitor, A-68064, and the ACE inhibitor methyl enalaprilat were synthesizedfrom (5S) 235,6-tetrahydro-S-benryI(bury2)-N-(tert-buto~car~nyl)~H~l fl-oxazine-2-ones la and 76, and (5s) 2.3,S,6-tetrahydro-5methyl-N-(fert-butoxycarbonyl)-4H-l.4-oxazine-2-one 12, respectively.

Effects of a 3-Alkyl-, 4-Hydroxy- and/or

Effects of a 3-Alkyl-, 4-Hydroxy- and/or 8-Aromatic-substituent on the Phenylethanolamine N-Methyltransferase Inhibitor Potency and α2-Adrenoceptor Affinity of 2,3,4,5-Tetrahydro-1H-2-benzazepines

✍ Gary L. Grunewald; Vilas H. Dahanukar; Kevin R. Criscione 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 635 KB

Synthesis and pharmacology of trans-4-n-

Synthesis and pharmacology of trans-4-n-propyl-3,4,4a,10b-tetrahydro-2H,5H-1-benzopyrano[4,3-b]1,4-oxazin-7- and -9-ols. The significance of nitrogen pka values for central dopamine receptor activation

✍ Dijkstra, Durk; Mulder, Theo B. A.; Rollema, Hans; Tepper, Pieter G.; Van der We 📂 Article 📅 1988 🏛 American Chemical Society 🌐 English ⚖ 721 KB