Prefabrication of a vascularized nerve graft by vessel implantation: Preliminary report of an experimental model
✍ Scribed by Dr. Pedro C. Cavadas; Francisco J. Vera-Sempere
- Publisher
- John Wiley and Sons
- Year
- 1994
- Tongue
- English
- Weight
- 518 KB
- Volume
- 15
- Category
- Article
- ISSN
- 0738-1085
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✦ Synopsis
Abstract
Regeneration through vascularized nerve grafts (VNG) seems to be better than nonvascularized nerve grafts (NVNG), especially in hostile beds. We report on an experimental technique of prefabrication of VNG by direct vessel implantation. An arteriovenous fistula was created in the groin region with autologous vein grafts in the Wistar rat model, and implanted into the sciatic nerve. Five weeks later the sciatic VNG was elevated on the prefabricated pedicle. The flap was free‐transferred orthotopically over a silicone sheet to impede plasmatic imbibition. Flap viability at 3 days was complete. India ink injection of the AV fistula resulted in capillary ink filling within the nerve and surrounding tissues. Histologic sections of the flap were examined, revealing its neovascularity. In an ongoing study, the regeneration through this prefabricated VNG is being compared to native VNG. © 1994 Wiley‐Liss, Inc.