Predictors of neck node control in radically irradiated squamous cell carcinoma of the oropharynx and laryngopharynx

✍ Scribed by Dr. Cherian Varghese; Dr. R. Sankaranarayanan; Dr. Balakrishnan Nair; Dr. M. Krishnan Nair

• Publisher: John Wiley and Sons
• Year: 1993
• Tongue: English
• Weight: 353 KB
• Volume: 15
• Category: Article
• ISSN: 1043-3074
• DOI: 10.1002/hed.2880150204

✦ Synopsis

Cases of squamous cell carcinoma (171) of the oropharynx and laryngopharynx with clinically positive neck nodes, treated primarily by radiotherapy, were used for a multivariate analysis of the factors related to the regional outcome. All patients were staged according to the UICC-TNM (1 982) classification. Lymph node size (P < 0.01), TNM nodal category (P < 0.05), and stage of the disease (P < 0.05) were significant in univariate analysis. Patient-and disease-related factors (age, sex, and histology) and treatment related factors (radiation dose (5000-6000 rads), radiation schedule, and concurrent chemotherapy) did not reach statistical significance. The stepwise logistic regression resulted in a final model with node size as the most important predictor of neck node control (P < 0.01). Patients with neck nodes up to 1 cm can receive radical radiotherapeutic management for treating the primary as well as nodal disease.