Predictors of 12-week remission in a nationwide cohort of people with depressive disorders: the CRESCEND study
✍ Scribed by Jae-Min Kim; Sung-Wan Kim; Robert Stewart; Seon-Young Kim; Jin-Sang Yoon; Sung-Won Jung; Min-Soo Lee; Hyeon-Woo Yim; Tae-Youn Jun
- Publisher
- John Wiley and Sons
- Year
- 2011
- Tongue
- English
- Weight
- 521 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0885-6222
- DOI
- 10.1002/hup.1168
No coin nor oath required. For personal study only.
✦ Synopsis
Abstract
Objective
To estimate the 12‐week remission rate of patients with depressive disorders and predictors of this in a naturalistic clinical setting in South Korea.
Methods
For people with DSM‐IV depressive disorders about to receive treatment at 18 hospitals, data on sociodemographic and health status were obtained. A free choice of clinical interventions was allowed and naturalistic follow‐up took place at 1, 2, 4, 8, and 12 weeks later. Remission was defined as a Hamilton Depression Rating Scale score of ≤7 sustained to 12 weeks or last follow‐up, if earlier.
Results
For 723 participants, the 12‐week remission rate was 31.4%. Remission was more likely in women, and in patients without a prior history of suicide attempt, and those with lower baseline anxiety.
Conclusions
Remission associated with unrestricted clinical interventions was comparable to STAR*D estimates for citalopram alone. Comorbid anxiety and a previous suicide attempt were markers of worse outcome. Copyright © 2011 John Wiley & Sons, Ltd.