Predictive value of hypoxia, proliferation and tyrosine kinase receptors for EGFR-inhibition and radiotherapy sensitivity in head and neck cancer models
β Scribed by Stegeman, Hanneke; Kaanders, Johannes H.; van der Kogel, Albert J.; Iida, Mari; Wheeler, Deric L.; Span, Paul N.; Bussink, Johan
- Book ID
- 122995307
- Publisher
- Elsevier Science
- Year
- 2013
- Tongue
- English
- Weight
- 946 KB
- Volume
- 106
- Category
- Article
- ISSN
- 0167-8140
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## Abstract ## Background This study was to explore whether the efficacy of the epidermal growth factor receptor (EGFR) tyrosine kinase inhibitor ZD1839 (Z, Iressa, gefitinib) plus chemotherapeutic agents docetaxel (D) and cisplatin (P) may benefit from sequencing of the combination. ## Methods
High expression of the epidermal growth factor receptor (EGFR) in breast carcinoma confers a growth advantage to the tumor cells. The EGFR tyrosine kinase inhibitor (EGFR-TKI) ZD1839 ('Iressa') has clinical activity in a wide range of tumor types, although the mechanism(s) by which it exerts its ant