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Predictive Value of CYP3A and ABCB1 Phenotyping Probes for the Pharmacokinetics of Sunitinib: the ClearSun Study

✍ Scribed by Kloth, Jacqueline S. L.; Klümpen, Heinz-Josef; Yu, Huixin; Eechoute, Karel; Samer, Caroline F.; Kam, Boen L. R.; Huitema, Alwin D. R.; Daali, Youssef; Zwinderman, Aeilko H.; Balakrishnar, Bavanthi; Bennink, Roelof J.; Wong, Mark; Schellens, Jan H. M.; Mathijssen, Ron H. J.; Gurney, Howard


Book ID
121549518
Publisher
Springer International Publishing AG
Year
2014
Tongue
English
Weight
554 KB
Volume
53
Category
Article
ISSN
0312-5963

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## Abstract Docetaxel is one of the most widely used anticancer drugs. A major problem with docetaxel treatment, however, is the considerable interpatient variability in docetaxel exposure. Another disadvantage of the drug is that it has a very low oral bioavailability and can, therefore, only be a