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Predictive testing for Huntington disease: interpretation and significance of intermediate alleles

✍ Scribed by A Semaka; S Creighton; S Warby; MR Hayden

Book ID
110888243
Publisher
John Wiley and Sons
Year
2006
Tongue
English
Weight
161 KB
Volume
70
Category
Article
ISSN
0009-9163

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After the discovery of genetic markers closely linked t o the gene for Huntington disease (HD) on chromosome 4 [Gusella et al., 19831, several centers in the U.S. and elsewhere began to offer a presymptomatic test for individuals at risk for this disorder. Since the mid-198O's, more than 1,000 perso