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Predictive DNA testing for multiple endocrine neoplasia 2: A therapeutic challenge of prophylactic thyroidectomy in very young children

✍ Scribed by L.W.Ernest van Heurn; Cees Schaap; George Sie; Anton A.M. Haagen; Willem J. Gerver; Gerard Freling; Hans-Kristian Ploos van Amstel; Erik Heineman

Book ID: 117161167
Publisher: Elsevier Science
Year: 1999
Tongue: English
Weight: 894 KB
Volume: 34
Category: Article
ISSN: 0022-3468
DOI: 10.1016/s0022-3468(99)90075-1

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## Abstract ## BACKGROUND Multiple endocrine neoplasia type 2 (MEN 2) is an inherited disease caused by germline mutations in the RET proto‐oncogene, and is responsible for the development of endocrine neoplasia. Its prognosis is dependent on the appearance and spread of medullary thyroid carcinom