Predictive and prognostic roles of ribonucleotide reductase M1 in resectable pancreatic adenocarcinoma
โ Scribed by Hao Xie; Wei Jiang; John Jiang; Yixin Wang; Richard Kim; Xiaobo Liu; Xiuli Liu
- Book ID
- 112067268
- Publisher
- John Wiley and Sons
- Year
- 2012
- Tongue
- English
- Weight
- 946 KB
- Volume
- 119
- Category
- Article
- ISSN
- 0008-543X
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## Abstract ## BACKGROUND: Pancreatic adenocarcinoma is a malignancy with a dismal prognosis. Previous studies have suggested that in pancreatic cancer, human equilibrative nucleoside transporter 1 (__hENT__โ__1__) and ribonucleoside reductase subunit M1 (__RRM1__) expression may have prognostic v
## Abstract Pancreatic cancer is the most lethal of all solid tumors partially because of its chemoresistance. Although gemcitabine is widely used as a first selected agent for the treatment of this disease despite low response rate, molecular mechanisms of gemcitabine resistance in pancreatic canc