Prediction of xenobiotic clearance in avian species using mammalian or avian data: how accurate is the prediction?

Role of fixed coefficients and exponents

Role of fixed coefficients and exponents in the prediction of human drug clearance: How accurate are the predictions from one or two species?

✍ Iftekhar Mahmood 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 193 KB

Pharmacokinetic (PK) interspecies scaling is generally conducted using PK data from at least three animal species but three animal species may not be always available. In a recent manuscript, Tang et al. have described the methods to predict human drug clearance using one or two animal species. The